DISEASES

Disease-gene associations mined from literature

Literature associating PPARG and acquired metabolic disease

PPARG [ENSP00000287820]

Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut homeostasis by suppressing NF-kappa-B-mediated proinflammatory responses. Plays a role in the regulation of cardiovascular circadian rhythms by regulating the transcription of ARNTL/BMAL1 in the blood vessels (By similarity); Nuclear hormone receptors

Synonyms:  PPARG,  D2KUA6,  E7EU07,  E7EUD1,  E9PFJ1 ...

Linkouts:  STRING  Pharos  UniProt  OMIM