DISEASES

Disease-gene associations mined from literature

Literature associating ZIC3 and ventricular septal defect

ZIC3 [ENSP00000287538]

Zinc finger protein of the cerebellum 3; Acts as transcriptional activator. Required in the earliest stages in both axial midline development and left-right (LR) asymmetry specification. Binds to the minimal GLI-consensus sequence 5'-GGGTGGTC-3'; Belongs to the GLI C2H2-type zinc-finger protein family.

Synonyms:  ZIC3,  ZIC3p,  hZIC3,  O60481,  O60481p ...

Linkouts:  STRING  Pharos  UniProt  OMIM