DISEASES

Disease-gene associations mined from literature

Literature associating MMP16 and osteochondrosis

MMP16 [ENSP00000286614]

Matrix metallopeptidase 16 (membrane-inserted); Endopeptidase that degrades various components of the extracellular matrix, such as collagen type III and fibronectin. Activates progelatinase A. Involved in the matrix remodeling of blood vessels. Isoform short cleaves fibronectin and also collagen type III, but at lower rate. It has no effect on type I, II, IV and V collagen. However, upon interaction with CSPG4, it may be involved in degradation and invasion of type I collagen by melanoma cells; Belongs to the peptidase M10A family.

Synonyms:  MMP16,  MMP16p,  hMMP16,  E5RJA7,  P51512 ...

Linkouts:  STRING  Pharos  UniProt  OMIM