Literature associating CASP10 and hypersensitivity reaction type IV disease
FAS-associated death domain protein interleukin-1B-converting enzyme 2; Involved in the activation cascade of caspases responsible for apoptosis execution. Recruited to both Fas- and TNFR-1 receptors in a FADD dependent manner. May participate in the granzyme B apoptotic pathways. Cleaves and activates caspase- 3, -4, -6, -7, -8, and -9. Hydrolyzes the small- molecule substrates, Tyr-Val-Ala-Asp-|-AMC and Asp-Glu-Val-Asp-|-AMC; Belongs to the peptidase C14A family.
Synonyms: CASP10, CASP10p, hCASP10, B4E3T5, CASP10-001 ...