DISEASES

Disease-gene associations mined from literature

Literature associating APP and Down syndrome

APP [ENSP00000284981]

Amyloid beta (A4) precursor protein; N-APP binds TNFRSF21 triggering caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6); Endogenous ligands

Synonyms:  APP,  B7Z313,  E9PEV0,  E9PG40,  H7C104 ...

Linkouts:  STRING  Pharos  UniProt  OMIM