Disease-gene associations mined from literature

Literature associating CXADR and myocarditis

CXADR [ENSP00000284878]

Coxsackie virus and adenovirus receptor; Component of the epithelial apical junction complex that may function as a homophilic cell adhesion molecule and is essential for tight junction integrity. Also involved in transepithelial migration of leukocytes through adhesive interactions with JAML a transmembrane protein of the plasma membrane of leukocytes. The interaction between both receptors also mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, JAML induces downstream cell signaling events in gamma-delta T-cells through PI3-kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T-cells that in turn stimulate epithelial tissues repair; IgCAM CXADR-related subfamily

Synonyms:  CXADR,  P78310,  P78310p,  hP78310,  1525 ...

Linkouts:  STRING  Pharos  UniProt  OMIM