DISEASES

Disease-gene associations mined from literature

Literature associating TMPRSS11D and severe acute respiratory syndrome

TMPRSS11D [ENSP00000283916]

Transmembrane protease, serine 11D; May play some biological role in the host defense system on the mucous membrane independently of or in cooperation with other substances in airway mucous or bronchial secretions. Plays a role in the proteolytic processing of ACE2. Proteolytically cleaves and activates the human coronavirus 229E (HCoV-229E) spike glycoprotein which facilitate virus-cell membrane fusions; spike proteins are synthesized and maintained in precursor intermediate folding states and proteolysis permits the refolding and energy release required to create stable virus-cell linkages and membrane coalescence. Preferentially cleaves the C-terminal side of arginine residues at the P1 position of certain peptides, cleaving Boc-Phe-Ser-Arg-4-methylcoumaryl-7-amide most efficiently and having an optimum pH of 8.6 with this substrate; Belongs to the peptidase S1 family.

Synonyms:  TMPRSS11D,  B4DL57,  HAT,  O60235,  Q4W5K4 ...

Linkouts:  STRING  Pharos  UniProt  OMIM