DISEASES

Disease-gene associations mined from literature

Literature associating GJA1 and dilated cardiomyopathy 1E

GJA1 [ENSP00000282561]

Gap junction protein, alpha 1, 43kDa; Gap junction protein that acts as a regulator of bladder capacity. A gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. May play a critical role in the physiology of hearing by participating in the recycling of potassium to the cochlear endolymph. Negative regulator of bladder functional capacity: acts by enhancing intercellular electrical and chemical transmission, thus sensitizing bladder muscles to cholinergic neural stimuli and causing them to contract (By similarity). May play a role in cell growth inhibition through the regulation of NOV expression and localization. Plays an essential role in gap junction communication in the ventricles (By similarity).

Synonyms:  GJA1,  GJA1p,  hGJA1,  B4DI81,  B4DMC9 ...

Linkouts:  STRING  Pharos  UniProt  OMIM