Disease-gene associations mined from literature

Literature associating CYSLTR2 and uveal melanoma

CYSLTR2 [ENSP00000282018]

G-protein coupled receptor GPCR21; Receptor for cysteinyl leukotrienes. The response is mediated via a G-protein that activates a phosphatidylinositol- calcium second messenger system. Stimulation by BAY u9773, a partial agonist, induces specific contractions of pulmonary veins and might also have an indirect role in the relaxation of the pulmonary vascular endothelium. The rank order of affinities for the leukotrienes is LTC4 = LTD4 >> LTE4.

Synonyms:  CYSLTR2,  CYSLTR2p,  hCYSLTR2,  KPG_011,  Q5KU17 ...

Linkouts:  STRING  Pharos  UniProt  OMIM