DISEASES

Disease-gene associations mined from literature

Literature associating FBXW7 and bladder adenocarcinoma

FBXW7 [ENSP00000281708]

F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase; Substrate recognition component of a SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes and binds phosphorylated sites/phosphodegrons within target proteins and thereafter bring them to the SCF complex for ubiquitination. Identified substrates include cyclin-E (CCNE1 or CCNE2), JUN, MYC, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1. Acts as a negative regulator of JNK signaling by binding to phosphorylated JUN and promoting its ubiquitination and subsequent degradation; F-box and WD repeat domain containing

Synonyms:  FBXW7,  FBXW7p,  hFBXW7,  A7BJS8,  B7Z2C8 ...

Linkouts:  STRING  Pharos  UniProt  OMIM