DISEASES

Disease-gene associations mined from literature

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Literature associating FREM2 and CAKUT

FREM2 [ENSP00000280481]

FRAS1-related extracellular matrix protein 2; Extracellular matrix protein required for maintenance of the integrity of the skin epithelium and for maintenance of renal epithelia . Required for epidermal adhesion . Involved in the development of eyelids and the anterior segment of the eyeballs . ; Belongs to the FRAS1 family.

Synonyms:  FREM2,  FREM2p,  hFREM2,  Q5SZK8,  Q5SZK8p ...

Linkouts:  STRING  Pharos  UniProt  OMIM

The disease-gene associations are derived from automatic text mining of the biomedical literature, manually curated database annotations, cancer mutation data, and genome-wide association studies. The confidence of each association is signified by stars, where ★★★★★ is the highest confidence and ★☆☆☆☆ is the lowest.

Developed by Sune Frankild, Alexander Junge, Albert Pallejà, Dhouha Grissa, Kalliopi Tsafou, and Lars Juhl Jensen from the Novo Nordisk Foundation Center for Protein Research.

Currently maintained by Qingyao Huang at Swiss Institute of Bioinformatics, University of Zurich. Licensed under CC BY 4.0.