DISEASES

Disease-gene associations mined from literature

Literature associating CD226 and NK cell deficiency

CD226 [ENSP00000280200]

DNAX accessory molecule 1; Involved in intercellular adhesion, lymphocyte signaling, cytotoxicity and lymphokine secretion mediated by cytotoxic T-lymphocyte (CTL) and NK cell. Cell surface receptor for NECTIN2. Upon ligand binding, stimulates T- cell proliferation and cytokine production, including that of IL2, IL5, IL10, IL13, and IFNG. Competes with PVRIG for NECTIN2-binding; CD molecules

Synonyms:  CD226,  CD226p,  hCD226,  J3QKM7,  J3QL19 ...

Linkouts:  STRING  Pharos  UniProt  OMIM