Literature associating DOCK5 and Li-Fraumeni syndrome 1
Dedicator of cytokinesis protein 5; Guanine nucleotide exchange factor (GEF) for Rho and Rac. GEF proteins activate small GTPases by exchanging bound GDP for free GTP (By similarity). Along with DOCK1, mediates CRK/CRKL regulation of epithelial and endothelial cell spreading and migration on type IV collagen; DOCK C2 domain containing
Synonyms: DOCK5, DOCK5p, hDOCK5, B9A015, Q9H7D0 ...