DISEASES

Disease-gene associations mined from literature

Literature associating TNFRSF10B and diffuse infiltrative lymphocytosis syndrome

TNFRSF10B [ENSP00000276431]

Tumor necrosis factor receptor superfamily, member 10b; Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B. Essential for ER stress-induced apoptosis; CD molecules

Synonyms:  TNFRSF10B,  B7Z3M7,  B7Z588,  DR5,  E9PBT3 ...

Linkouts:  STRING  Pharos  UniProt  OMIM