DISEASES

Disease-gene associations mined from literature

Literature associating DOCK11 and shoulder impingement syndrome

DOCK11 [ENSP00000276202]

Activated Cdc42-associated guanine nucleotide exchange factor; Guanine nucleotide-exchange factor (GEF) that activates CDC42 by exchanging bound GDP for free GTP. Required for marginal zone (MZ) B-cell development, is associated with early bone marrow B-cell development, MZ B-cell formation, MZ B-cell number and marginal metallophilic macrophages morphology. Facilitates filopodia formation through the activation of CDC42; Belongs to the DOCK family.

Synonyms:  DOCK11,  DOCK11p,  hDOCK11,  A6NIW2,  B3KNP4 ...

Linkouts:  STRING  Pharos  UniProt  OMIM