DISEASES

Disease-gene associations mined from literature

Literature associating CISD2 and diabetes insipidus

CISD2 [ENSP00000273986]

Endoplasmic reticulum intermembrane small protein; Regulator of autophagy that contributes to antagonize BECN1-mediated cellular autophagy at the endoplasmic reticulum. Participates in the interaction of BCL2 with BECN1 and is required for BCL2-mediated depression of endoplasmic reticulum Ca(2+) stores during autophagy. Contributes to BIK-initiated autophagy, while it is not involved in BIK-dependent activation of caspases. Involved in life span control, probably via its function as regulator of autophagy; CDGSH iron sulfur domain containing

Synonyms:  CISD2,  CISD2p,  hCISD2,  D6RCF4,  I3L1N9 ...

Linkouts:  STRING  Pharos  UniProt  OMIM