Literature associating CISD2 and Wolfram syndrome
Endoplasmic reticulum intermembrane small protein; Regulator of autophagy that contributes to antagonize BECN1-mediated cellular autophagy at the endoplasmic reticulum. Participates in the interaction of BCL2 with BECN1 and is required for BCL2-mediated depression of endoplasmic reticulum Ca(2+) stores during autophagy. Contributes to BIK-initiated autophagy, while it is not involved in BIK-dependent activation of caspases. Involved in life span control, probably via its function as regulator of autophagy; CDGSH iron sulfur domain containing
Synonyms: CISD2, CISD2p, hCISD2, D6RCF4, I3L1N9 ...