Literature associating CTDSPL and autosomal recessive chronic granulomatous disease cytochrome b-positive type II
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like; Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells (By similarity). Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation; CTD family phosphatases
Synonyms: CTDSPL, F8WED2, H7C2S4, O15194, C3orf8 ...