Disease-gene associations mined from literature

Literature associating MARCH4 and multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia and hydranencephaly

MARCH4 [ENSP00000273067]

Membrane-associated ring finger (C3HC4) 4, E3 ubiquitin protein ligase; E3 ubiquitin-protein ligase that may mediate ubiquitination of MHC-I and CD4, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin- conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates; Membrane associated ring-CH-type fingers

Synonyms:  MARCH4,  MARCH4p,  hMARCH4,  Q9P2E8,  KIAA1399 ...

Linkouts:  STRING  Pharos  UniProt  OMIM