Disease-gene associations mined from literature

Literature associating TPRKB and lower urinary tract calculus

TPRKB [ENSP00000272424]

EKC/KEOPS complex subunit TPRKB; Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. TPRKB acts as an allosteric effector that regulates the t(6)A activity of the complex. TPRKB is not required for tRNA modification (By similarity); Belongs to the CGI121/TPRKB family.

Synonyms:  TPRKB,  Q9Y3C4,  CGI-121,  My019,  Q9Y3C4p ...

Linkouts:  STRING  Pharos  UniProt  OMIM