DISEASES

Disease-gene associations mined from literature

Literature associating IFNAR1 and hepatitis C

IFNAR1 [ENSP00000270139]

Interferon (alpha, beta and omega) receptor 1; Component of the receptor for type I interferons, including interferons alpha, IFNB1 and IFNW1. Functions in general as heterodimer with IFNAR2. Type I interferon binding activates the JAK-STAT signaling cascade, and triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and the IFNR alpha- and beta- subunits themselves. Can form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway (By similarity).

Synonyms:  IFNAR1,  IFNAR1p,  hIFNAR1,  C9J114,  P17181 ...

Linkouts:  STRING  Pharos  UniProt  OMIM