Disease-gene associations mined from literature

Literature associating IRF8 and tuberculous salpingitis

IRF8 [ENSP00000268638]

Interferon consensus sequence-binding protein; Plays a role as a transcriptional activator or repressor. Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)). Plays a negative regulatory role in cells of the immune system. Involved in CD8(+) dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA-3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF8 and activation of genes (By similarity).

Synonyms:  IRF8,  IRF8p,  hIRF8,  H3BPS5,  H3BQH6 ...

Linkouts:  STRING  Pharos  UniProt  OMIM