Disease-gene associations mined from literature

Literature associating MAP1LC3B and liver carcinoma in situ

MAP1LC3B [ENSP00000268607]

Microtubule-associated proteins 1A/1B light chain 3B; Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes). Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation. Promotes primary ciliogenesis by removing OFD1 from centriolar satellites via the autophagic pathway; Belongs to the ATG8 family.

Synonyms:  MAP1LC3B,  DKFZP762B153,  H3BM99,  H3BTE7,  H3BTL1 ...

Linkouts:  STRING  Pharos  UniProt  OMIM