DISEASES

Disease-gene associations mined from literature

Literature associating CRTC3 and hidradenoma

CRTC3 [ENSP00000268184]

Transducer of regulated cAMP response element-binding protein 3; Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR).

Synonyms:  CRTC3,  CRTC3p,  hCRTC3,  H0YK33,  Q6UUV7 ...

Linkouts:  STRING  Pharos  UniProt  OMIM