DISEASES

Disease-gene associations mined from literature

Literature associating MFGE8 and Diamond-Blackfan anemia 9

MFGE8 [ENSP00000268150]

Milk fat globule-EGF factor 8 protein; Plays an important role in the maintenance of intestinal epithelial homeostasis and the promotion of mucosal healing. Promotes VEGF-dependent neovascularization (By similarity). Contributes to phagocytic removal of apoptotic cells in many tissues. Specific ligand for the alpha-v/beta-3 and alpha-v/beta-5 receptors. Also binds to phosphatidylserine-enriched cell surfaces in a receptor-independent manner. Zona pellucida-binding protein which may play a role in gamete interaction. Binds specifically to rotavirus and inhibits its replication.

Synonyms:  MFGE8,  LOC102723860,  LOC102724554,  MFGE8p,  hMFGE8 ...

Linkouts:  STRING  Pharos  UniProt  OMIM