DISEASES

Disease-gene associations mined from literature

Literature associating ERBB3 and transitional cell carcinoma

ERBB3 [ENSP00000267101]

V-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3; Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins. Binds to neuregulin-1 (NRG1) and is activated by it; ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase. May also be activated by CSPG5.

Synonyms:  ERBB3,  ERBB3p,  hERBB3,  B3KWG5,  B4DGQ7 ...

Linkouts:  STRING  Pharos  UniProt  OMIM