Literature associating ERBB3 and estrogen-receptor positive breast cancer
V-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3; Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins. Binds to neuregulin-1 (NRG1) and is activated by it; ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase. May also be activated by CSPG5.
Synonyms: ERBB3, ERBB3p, hERBB3, B3KWG5, B4DGQ7 ...