Literature associating TIMP3 and proliferative diabetic retinopathy
Tissue inhibitor of metalloproteinases 3; Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. May form part of a tissue-specific acute response to remodeling stimuli. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-9, MMP-13, MMP-14 and MMP-15.
Synonyms: TIMP3, TIMP3p, hTIMP3, P35625, TIMP3-001 ...