Disease-gene associations mined from literature

Literature associating POLB and basal ganglia cerebrovascular disease

POLB [ENSP00000265421]

Polymerase (DNA directed), beta; Repair polymerase that plays a key role in base-excision repair. Has 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity that removes the 5' sugar phosphate and also acts as a DNA polymerase that adds one nucleotide to the 3' end of the arising single-nucleotide gap. Conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases.

Synonyms:  POLB,  LOC102723810,  B7Z1W5,  E5RG65,  E5RHZ4 ...

Linkouts:  STRING  Pharos  UniProt  OMIM