Literature associating POLB and basal ganglia cerebrovascular disease
POLB [ENSP00000265421]
DNA polymerase beta; Repair polymerase that plays a key role in base-excision repair. Has 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity that removes the 5' sugar phosphate and also acts as a DNA polymerase that adds one nucleotide to the 3' end of the arising single-nucleotide gap. Conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases.
Synonyms: POLB, E5RG65, E5RHZ4, E5RIJ0, E5RJ55 ...