Disease-gene associations mined from literature

Literature associating VDAC1 and typhoid fever

VDAC1 [ENSP00000265333]

Voltage-dependent anion-selective channel protein 1; Forms a channel through the mitochondrial outer membrane and also the plasma membrane. The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules; in the plasma membrane it is involved in cell volume regulation and apoptosis. It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective. May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis; Belongs to the eukaryotic mitochondrial porin family.

Synonyms:  VDAC1,  VDAC1p,  hVDAC1,  C9JI87,  P21796 ...

Linkouts:  STRING  Pharos  UniProt  OMIM