DISEASES

Disease-gene associations mined from literature

Literature associating TNC and interstitial keratitis

TNC [ENSP00000265131]

Glioma-associated-extracellular matrix antigen; Extracellular matrix protein implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity as well as neuronal regeneration. Promotes neurite outgrowth from cortical neurons grown on a monolayer of astrocytes. Ligand for integrins alpha-8/beta-1, alpha-9/beta-1, alpha-V/beta-3 and alpha-V/beta-6. In tumors, stimulates angiogenesis by elongation, migration and sprouting of endothelial cells; Belongs to the tenascin family.

Synonyms:  TNC,  A9YUB8,  E9PC84,  F5H5D6,  F5H7V9 ...

Linkouts:  STRING  Pharos  UniProt  OMIM