Literature associating SLC1A3 and Alexander disease
Solute carrier family 1 (glial high affinity glutamate transporter), member 3; Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate. Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion. Mediates Cl(-) flux that is not coupled to amino acid transport; this avoids the accumulation of negative charges due to aspartate and Na(+) symport. Plays a redundant role in the rapid removal of released glutamate from the synaptic cleft, which is essential for terminating the postsynaptic action of glutamate (By similarity); Solute carriers
Synonyms: SLC1A3, SLC1A3p, hSLC1A3, A0A024R050, B4DF14 ...