Disease-gene associations mined from literature

Literature associating IL11 and neutropenia

IL11 [ENSP00000264563]

Interleukin-11; Cytokine that stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production . Also promotes the proliferation of hepatocytes in response to liver damage. Binding to its receptor formed by IL6ST and either IL11RA1 or IL11RA2 activates a signaling cascade that promotes cell proliferation . Signaling leads to the activation of intracellular protein kinases and the phosphorylation of STAT3. ; Belongs to the IL-6 superfamily.

Synonyms:  IL11,  IL11p,  hIL11,  A8K3F7,  K7ESD5 ...

Linkouts:  STRING  Pharos  UniProt  OMIM