DISEASES

Disease-gene associations mined from literature

Literature associating IL21 and common variable immunodeficiency

IL21 [ENSP00000264497]

Interleukin 21; Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG(1) and IgG(3) in B-cells (By similarity). May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells. During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation; Interleukins

Synonyms:  IL21,  IL21p,  hIL21,  Q9HBE4,  Q9HBE4p ...

Linkouts:  STRING  Pharos  UniProt  OMIM