Disease-gene associations mined from literature

Literature associating FNIP2 and multilocular clear cell renal cell carcinoma

FNIP2 [ENSP00000264433]

O6-methylguanine-induced apoptosis 1 protein; Acts as a co-chaperone of HSP90AA1. Inhibits the ATPase activity of HSP90AA1 leading to reduction in its chaperone activity. Facilitates the binding of client protein FLCN to HSP90AA1. May play a role in the signal transduction pathway of apoptosis induced by O6-methylguanine- mispaired lesions (By similarity). May be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways. May regulate phosphorylation of RPS6KB1; DENN/MADD domain containing

Synonyms:  FNIP2,  FNIP2p,  hFNIP2,  D6RFH5,  FNIP2-001 ...

Linkouts:  STRING  Pharos  UniProt  OMIM