DISEASES

Disease-gene associations mined from literature

Literature associating PRKG2 and cystic fibrosis

PRKG2 [ENSP00000264399]

Protein kinase, cGMP-dependent, type II; Crucial regulator of intestinal secretion and bone growth (By similarity). Phosphorylates and activates CFTR on the plasma membrane. Plays a key role in intestinal secretion by regulating cGMP-dependent translocation of CFTR in jejunum (By similarity). Acts downstream of NMDAR to activate the plasma membrane accumulation of GRIA1/GLUR1 in synapse and increase synaptic plasticity. Phosphorylates GRIA1/GLUR1 at Ser-863 (By similarity). Acts as regulator of gene expression and activator of the extracellular signal-regulated kinases MAPK3/ERK1 and MAPK1/ERK2 in mechanically stimulated osteoblasts. Under fluid shear stress, mediates ERK activation and subsequent induction of FOS, FOSL1/FRA1, FOSL2/FRA2 and FOSB that play a key role in the osteoblast anabolic response to mechanical stimulation (By similarity); Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cGMP subfamily.

Synonyms:  PRKG2,  PRKG2p,  hPRKG2,  B7ZA25,  Q13237 ...

Linkouts:  STRING  Pharos  UniProt  OMIM