Literature associating SRD5A3 and congenital disorder of glycosylation type II
3-oxo-5-alpha-steroid 4-dehydrogenase 3; Plays a key role in early steps of protein N-linked glycosylation by being required for the conversion of polyprenol into dolichol. Dolichols are required for the synthesis of dolichol-linked monosaccharides and the oligosaccharide precursor used for N-glycosylation. Acts as a polyprenol reductase that promotes the reduction of the alpha-isoprene unit of polyprenols into dolichols in a NADP-dependent mechanism. Also able to convert testosterone (T) into 5-alpha-dihydrotestosterone (DHT).
Synonyms: SRD5A3, SRD5A3p, hSRD5A3, H0Y9P9, Q9H8P0 ...