DISEASES

Disease-gene associations mined from literature

Literature associating SELP and venous insufficiency

SELP [ENSP00000263686]

Platelet activation dependent granule-external membrane protein; Ca(2+)-dependent receptor for myeloid cells that binds to carbohydrates on neutrophils and monocytes. Mediates the interaction of activated endothelial cells or platelets with leukocytes. The ligand recognized is sialyl-Lewis X. Mediates rapid rolling of leukocyte rolling over vascular surfaces during the initial steps in inflammation through interaction with PSGL1; Belongs to the selectin/LECAM family.

Synonyms:  SELP,  A0A024R8Y9,  F6VVT6,  P16109,  Q5R341 ...

Linkouts:  STRING  Pharos  UniProt  OMIM