Literature associating NOTCH3 and T-cell acute lymphoblastic leukemia
Neurogenic locus notch homolog protein 3; Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity).
Synonyms: NOTCH3, NOTCH3p, hNOTCH3, M0R3C9, NOTCH3-001 ...