DISEASES

Disease-gene associations mined from literature

Literature associating NOX4 and drug-induced hearing loss

NOX4 [ENSP00000263317]

Kidney superoxide-producing NADPH oxidase; Constitutive NADPH oxidase which generates superoxide intracellularly upon formation of a complex with CYBA/p22phox. Regulates signaling cascades probably through phosphatases inhibition. May function as an oxygen sensor regulating the KCNK3/TASK-1 potassium channel and HIF1A activity. May regulate insulin signaling cascade. May play a role in apoptosis, bone resorption and lipolysaccharide-mediated activation of NFKB. May produce superoxide in the nucleus and play a role in regulating gene expression upon cell stimulation. Isoform 3 is not functional. Isoform 5 and isoform 6 display reduced activity.

Synonyms:  NOX4,  NOX4p,  hNOX4,  E9PI95,  E9PPP2 ...

Linkouts:  STRING  Pharos  UniProt  OMIM