DISEASES

Disease-gene associations mined from literature

Literature associating UCP1 and obesity

UCP1 [ENSP00000262999]

Uncoupling protein 1 (mitochondrial, proton carrier); Mitochondrial protein responsible for thermogenic respiration, a specialized capacity of brown adipose tissue and beige fat that participates to non-shivering adaptive thermogenesis to temperature and diet variations and more generally to the regulation of energy balance (By similarity). Functions as a long-chain fatty acid/LCFA and proton symporter, simultaneously transporting one LCFA and one proton through the inner mitochondrial membrane. However, LCFAs remaining associated with the transporter via their hydrophobic tails, it results in an apparent transport of protons activated by LCFAs. Thereby, dissipates the mitochondrial proton gradient and converts the energy of substrate oxydation into heat instead of ATP. Regulates the production of reactive oxygen species/ROS by mitochondria (By similarity); Solute carriers

Synonyms:  UCP1,  UCP1p,  hUCP1,  P25874,  Q4KMT7 ...

Linkouts:  STRING  Pharos  UniProt  OMIM