Disease-gene associations mined from literature

Literature associating TCF3 and adult acute lymphocytic leukemia

TCF3 [ENSP00000262965]

Immunoglobulin enhancer-binding factor E12/E47; Transcriptional regulator. Involved in the initiation of neuronal differentiation. Heterodimers between TCF3 and tissue- specific basic helix-loop-helix (bHLH) proteins play major roles in determining tissue-specific cell fate during embryogenesis, like muscle or early B-cell differentiation. Dimers bind DNA on E- box motifs: 5'-CANNTG-3'. Binds to the kappa-E2 site in the kappa immunoglobulin gene enhancer. Binds to IEB1 and IEB2, which are short DNA sequences in the insulin gene transcription control region.

Synonyms:  TCF3,  TCF3p,  hTCF3,  B1NYC3,  K7EJN4 ...

Linkouts:  STRING  Pharos  UniProt  OMIM