Disease-gene associations mined from literature

Literature associating BPI and primary sclerosing cholangitis

BPI [ENSP00000262865]

Bactericidal permeability-increasing protein; The cytotoxic action of BPI is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope. Has antibacterial activity against the Gram-nagative bacterium P.aeruginosa, this activity is inhibited by LPS from P.aeruginosa; Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.

Synonyms:  LOC149684,  A2A2A1,  A2A2A2,  B4DKH6,  BPI-001 ...

Linkouts:  STRING  Pharos  UniProt  OMIM