DISEASES

Disease-gene associations mined from literature

Literature associating SRCAP and Rubinstein-Taybi syndrome

SRCAP [ENSP00000262518]

Snf2-related CREBBP activator protein; Catalytic component of the SRCAP complex which mediates the ATP-dependent exchange of histone H2AZ/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling. Acts as a coactivator for CREB-mediated transcription, steroid receptor-mediated transcription, and Notch-mediated transcription; Belongs to the SNF2/RAD54 helicase family. SWR1 subfamily.

Synonyms:  SRCAP,  LOC100862671,  C9J4U4,  G1UI29,  Q6ZRS2 ...

Linkouts:  STRING  Pharos  UniProt  OMIM