DISEASES

Disease-gene associations mined from literature

Literature associating ITGA2B and essential thrombocythemia

ITGA2B [ENSP00000262407]

Integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41); Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha- IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface; CD molecules

Synonyms:  ITGA2B,  ITGA2Bp,  hITGA2B,  F1C626,  I6XCH0 ...

Linkouts:  STRING  Pharos  UniProt  OMIM