DISEASES

Disease-gene associations mined from literature

Literature associating MGRN1 and amyotrophic lateral sclerosis type 22

MGRN1 [ENSP00000262370]

Mahogunin ring finger 1, E3 ubiquitin protein ligase; E3 ubiquitin-protein ligase. Mediates monoubiquitination at multiple sites of TSG101 in the presence of UBE2D1, but not of UBE2G1, nor UBE2H. Plays a role in the regulation of endosome-to- lysosome trafficking. Impairs MC1R- and MC4R-signaling by competing with GNAS-binding to MCRs and inhibiting agonist-induced cAMP production. Does not inhibit ADRB2-signaling. Does not promote MC1R ubiquitination; Ring finger proteins

Synonyms:  MGRN1,  MGRN1p,  hMGRN1,  B4DR12,  E9PB19 ...

Linkouts:  STRING  Pharos  UniProt  OMIM