Literature associating TRIM37 and neurodegeneration with brain iron accumulation 6
RING-type E3 ubiquitin transferase TRIM37; E3 ubiquitin-protein ligase required to prevent centriole reduplication. Probably acts by ubiquitinating positive regulators of centriole reduplication. Mediates monoubiquitination of 'Lys-119' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression: associates with some Polycomb group (PcG) multiprotein PRC2-like complex and mediates repression of target genes. Has anti-HIV activity; Belongs to the TRIM/RBCC family.
Synonyms: TRIM37, TRIM37p, hTRIM37, A8K0V9, B3KMU3 ...