DISEASES

Disease-gene associations mined from literature

Literature associating TRIM37 and neurodegeneration with brain iron accumulation 6

TRIM37 [ENSP00000262294]

RING-type E3 ubiquitin transferase TRIM37; E3 ubiquitin-protein ligase required to prevent centriole reduplication. Probably acts by ubiquitinating positive regulators of centriole reduplication. Mediates monoubiquitination of 'Lys-119' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression: associates with some Polycomb group (PcG) multiprotein PRC2-like complex and mediates repression of target genes. Has anti-HIV activity; Belongs to the TRIM/RBCC family.

Synonyms:  TRIM37,  TRIM37p,  hTRIM37,  A8K0V9,  B3KMU3 ...

Linkouts:  STRING  Pharos  UniProt  OMIM