Disease-gene associations mined from literature

Literature associating MCM4 and breast giant fibroadenoma

MCM4 [ENSP00000262105]

Minichromosome maintenance complex component 4; Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.

Synonyms:  MCM4,  MCM4p,  hMCM4,  A4FS09,  E5RFJ8 ...

Linkouts:  STRING  Pharos  UniProt  OMIM