DISEASES

Disease-gene associations mined from literature

Literature associating MEOX2 and vesicoureteral reflux

MEOX2 [ENSP00000262041]

Growth arrest-specific homeobox; Mesodermal transcription factor that plays a key role in somitogenesis and is required for sclerotome development (By similarity). Activates expression of CDKN1A and CDKN2A in endothelial cells, acting as a regulator of vascular cell proliferation. While it activates CDKN1A in a DNA-dependent manner, it activates CDKN2A in a DNA-independent manner. May have a regulatory role when quiescent vascular smooth muscle cells reenter the cell cycle; HOXL subclass homeoboxes

Synonyms:  MEOX2,  MEOX2p,  hMEOX2,  A4D127,  MEOX2-001 ...

Linkouts:  STRING  Pharos  UniProt  OMIM