DISEASES

Disease-gene associations mined from literature

Literature associating SEMA7A and exotropia

SEMA7A [ENSP00000261918]

Semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group); Plays an important role in integrin-mediated signaling and functions both in regulating cell migration and immune responses. Promotes formation of focal adhesion complexes, activation of the protein kinase PTK2/FAK1 and subsequent phosphorylation of MAPK1 and MAPK3. Promotes production of proinflammatory cytokines by monocytes and macrophages. Plays an important role in modulating inflammation and T-cell-mediated immune responses. Promotes axon growth in the embryonic olfactory bulb. Promotes attachment, spreading and dendrite outgrowth in melanocytes; Belongs to the semaphorin family.

Synonyms:  SEMA7A,  SEMA7Ap,  hSEMA7A,  B3KMH6,  F5GYX3 ...

Linkouts:  STRING  Pharos  UniProt  OMIM